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FIGURE 3 FISH image by using fast prenatal X,Y and 18 Enumeration Probe kit (green signal for X and red signals for Y chromosome). 4 of 6 | RAJABADEH 1 23.49,XXXXY syndrome, first described by Fraccaro in 1960 , is a rare aneuploidy with an incidence of 1/85 000–100 000 . It is characterised by the presence of three extra X chromosomes in subjects who are phenotypically male. This aneuploidy probably originates from non-disjunction of the X chromosome during both meiosis I and II.Fraccaro's syndrome is caused by 49,XXXXY chromosomal aneuploidy and is often classified as a Klinefelter's syndrome variant. Two prevailing theories have been made to account for the phenotype associated with a 49,XXXXY genotype as well as for the other X chromosome aneuploidies. AI text to image generator. Generate AI art from text, completely free, online, no login or sign-up, no daily credit limits/restrictions/gimmicks, and it's fast. 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